What Is BPC-157? Research Evidence & FDA Status

Name: NOVABIO BPC-157 reviewed research dataset
Creator: NOVABIO
License: https://novabiohealthy.com/pages/terms-of-service

What Is BPC-157?

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide research compound. Its research record is organized here by molecular identity, registry data, published evidence and current FDA context. The reviewed literature discusses several proposed biological pathways, but no single validated human receptor target has been established. NOVABIO product and COA records are presented separately from clinical evidence.

Evidence boundary

Clinical evidence, product identity and batch documentation are separate records. This page does not provide dosing, administration or treatment recommendations.

Evidence at a Glance

4ClinicalTrials.gov records

233PubMed query records

6Selected publications

2Exact product COA records

Very limited

Human evidence

Small pilot publications and a small number of registry records do not establish broad safety or effectiveness.

Predominantly preclinical

Musculoskeletal research

Much of the cited healing literature uses animal or laboratory models and cannot be generalized to human outcomes.

Unresolved

Translation and safety

Form, impurities, immunogenicity, route and study quality remain material limitations identified in reviews and FDA materials.

Counts are synchronized search records, not a quality score or proof of efficacy.

Sources: PubMed search results · ClinicalTrials.gov records · Retrieved 2026-10-06

Mechanism & Pharmacology

The reviewed literature discusses several proposed biological pathways, but no single validated human receptor target has been established.

Source: PubMed search results · Retrieved 2026-10-06

Clinical Development

4 decision-relevant records are shown on desktop and up to three on mobile. Use the official registry link below to review all 4 synchronized search records.

NCT ID / Study	Phase	Status	Context	Sponsor	Last registry update
NCT07437547BPC 157 for Acute Hamstring Muscle Strain Repair	Phase 2	Recruiting	Hamstring Muscle Strain, Skeletal Muscle Injury	Hudson Biotech	2026-02-27
NCT07803250Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery	Phase 1	Not Yet Recruiting	Rotator Cuff Tear	University of Arkansas	2026-09-03
NCT02637284PCO-02 - Safety and Pharmacokinetics Trial	Phase 1	Unknown	Healthy Volunteers	PharmaCotherapia d.o.o.	2015-12-22
NCT07752381A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery	NA	Completed	Musculoskeletal Inflammation, Exercise-Induced Muscle Damage, Post-Exercise Recovery, Musculoskeletal Pain	Parlay Wellness	2026-08-07

Source: ClinicalTrials.gov records · Retrieved 2026-10-06

Published Study OutcomesEvidence-level interpretation

Published Study Outcomes

Human pilot observations

Published pilot reports are small and exploratory; they do not establish efficacy or a general safety profile.

Systematic review

A sports-medicine review found a literature base dominated by preclinical work and emphasized the limited human evidence.

Preclinical healing models

Animal studies report model-specific findings across tissues, but animal outcomes are not clinical treatment evidence.

Source: PubMed search results · Retrieved 2026-10-06

Identity & ChemistryForm-specific database fields

Identity & Chemistry

PubChem record: CID 9941957 · Bpc-157
Molecular formula: C62H98N16O22
Molecular weight: 1419.5 g/mol
InChIKey: HEEWEZGQMLZMFE-RKGINYAYSA-N

These fields apply to the cited PubChem record. Salt, counter-ion, hydration state and formulation must be confirmed from the actual product or batch record.

Source: PubChem CID 9941957 · Retrieved 2026-10-06

Research Tools for BPC-157

Review the selected records above or open the official registry for the complete result set.

Open all ClinicalTrials.gov records

Certificate strength

Select a listed strength to review the corresponding batch documentation.

Storage & Laboratory HandlingDocumentation-led controls

Storage & Laboratory Handling

Confirm the exact material form, lot, supplied state and storage statement from the product label and corresponding batch documentation. Do not infer handling conditions from a different compound, strength or external clinical publication.

Regulatory Status

FDA identifies BPC-157 among bulk drug substances that may present significant safety risks for compounding and notes limited safety information for proposed routes of administration.

Source: FDA official information · Retrieved 2026-10-06

Research TimelineSelected milestones

Research Timeline

1990s
Early BPC-157 preclinical publications appeared.
1999
A rabbit bone-defect study was indexed in PubMed.
2024
A small interstitial-cystitis pilot publication was indexed.
2025
Human pilot and systematic-review publications expanded the limited clinical discussion.
2026
FDA, registry and PubMed records were resynchronized for this profile.

Selected Literature6 reviewed records

Selected Literature

Reviewed publication

Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.

Alternative therapies in health and medicine · 2024 Oct

PMID 39325560

Reviewed publication

Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.

Alternative therapies in health and medicine · 2025 Sep

PMID 40131143

Reviewed publication

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025 Nov

PMID 40756949

Reviewed publication

Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.

Current reviews in musculoskeletal medicine · 2025 Dec

PMID 40789979

Reviewed publication

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.

Cell and tissue research · 2019 Aug

PMID 30915550

Reviewed publication

Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.

Bone · 1999 Mar

PMID 10071911

Source: PubMed search results · Retrieved 2026-10-06

Authoritative Data Summary

BPC-157 Research Summary

Identity

BPC-157 is identified in this profile as synthetic pentadecapeptide research compound; identity fields are tied to PubChem CID 9941957 and must be interpreted for that recorded form.

Mechanism

The reviewed literature discusses several proposed biological pathways, but no single validated human receptor target has been established.

Evidence

the synchronized searches returned 4 ClinicalTrials.gov records and 233 PubMed records. Registry counts include records of different designs and statuses, while publication counts include multiple evidence types; neither count is a quality score. Evidence must be separated by level: a registry entry describes a protocol, a publication reports a defined analysis, and a preclinical experiment does not establish a human outcome. Dates, recruitment status and regulatory information can change, which is why this profile shows a verification date and links to current official search pages.

Regulatory context

FDA identifies BPC-157 among bulk drug substances that may present significant safety risks for compounding and notes limited safety information for proposed routes of administration. Clinical findings apply only to the studied drug product, formulation, population and protocol. NOVABIO product specifications and batch documentation are separate catalogue records and do not inherit clinical outcomes from external studies. This profile therefore supports source tracing and compound comparison, but it does not certify a batch, recommend treatment, provide dosing instructions or replace current FDA labeling and professional medical judgment.

Sources: PubMed · ClinicalTrials.gov · PubChem · FDA

FAQ4 evidence-bounded answers

BPC-157 FAQ

What is BPC-157?

BPC-157 is a synthetic 15-amino-acid peptide used in research literature and commonly described as a stable gastric pentadecapeptide.

Is BPC-157 FDA approved?

No FDA-approved BPC-157 drug is identified in the reviewed FDA materials.

Is BPC-157 supported by human clinical evidence?

Human evidence remains limited and includes small pilot reports; much of the literature is preclinical.

Does this page provide dosing guidance?

No. This page does not provide dosing, administration or treatment instructions.

Complete ReferencesReviewed identifiers; links consolidated by module

Complete References

NCT07437547 — BPC 157 for Acute Hamstring Muscle Strain Repair
NCT07803250 — Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery
NCT02637284 — PCO-02 - Safety and Pharmacokinetics Trial
NCT07752381 — A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery
PMID 39325560 — Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.
PMID 40131143 — Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.
PMID 40756949 — Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.
PMID 40789979 — Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.
PMID 30915550 — Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.
PMID 10071911 — Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.
PubChem CID 9941957 — Bpc-157
FDA regulatory source listed in the Regulatory Status module.

Sources, Methodology & Last Verified

Official sources: ClinicalTrials.gov, NCBI PubMed, PubChem, FDA, and NOVABIO product and COA records.
Inclusion: Exact BPC-157 or Body Protection Compound-157 identity and traceable registry, publication, chemistry, regulatory or batch fields.
Exclusion: News, supplier blogs, community posts, duplicate records and claims not tied to a reviewed source.
Last verified: October 6, 2026
Prepared by: NOVABIO Research
Corrections: Contact NOVABIO with the page URL and source record.